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Graft-Versus-Host Disease

In this video, Dr. Duncan speaks about the pathophysiology, diagnosis, and general management approach to the prevention and treatment of graft-versus-host-disease (GVHD) in pediatric patients post-hematapoetic stem cell transplantation.

Released:

April 11, 2017

Audience:

Physicians, Nurses

Learning Objectives
  • Identify transplant‑related factors and manifestations of graft‑versus‑host disease that increase risk for respiratory compromise and airway intervention

  • Explain how acute and chronic pulmonary graft‑versus‑host disease alter airway physiology, lung mechanics, and ventilation strategies

  • Apply early recognition of pulmonary GVHD features to anticipate the need for escalated respiratory support, including endotracheal intubation

  • Analyze clinical and diagnostic findings of graft‑versus‑host disease to assess airway risk and readiness for mechanical ventilation

  • Evaluate respiratory progression, immunosuppression status, and organ involvement to guide safe airway planning in patients with graft‑versus‑host disease

Author(s)

Christine Duncan, MD

Senior Physician | Dana-Farber

Boston Children's Cancer and Blood Disorders Center

Medical Director of Clinical Research and Clinical Development, Gene Therapy Program | Boston Children’s Hospital

Associate Professor of Pediatrics | Harvard Medical School


Lisa DelSignore, MD

Associate Professor, Fellowship Program Director, Pediatric Critical Care Medicine | Yale University

Citation

Duncan C, DelSignore L. Graft-Versus-Host Disease. 3/2017. Online Video. OPENPediatrics. https://learn.openpediatrics.org/learn/course/internal/view/elearning/3255/graft-versus-host-disease.

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