Graft-Versus-Host Disease

Learning Objectives
Identify transplant‑related factors and manifestations of graft‑versus‑host disease that increase risk for respiratory compromise and airway intervention
Explain how acute and chronic pulmonary graft‑versus‑host disease alter airway physiology, lung mechanics, and ventilation strategies
Apply early recognition of pulmonary GVHD features to anticipate the need for escalated respiratory support, including endotracheal intubation
Analyze clinical and diagnostic findings of graft‑versus‑host disease to assess airway risk and readiness for mechanical ventilation
Evaluate respiratory progression, immunosuppression status, and organ involvement to guide safe airway planning in patients with graft‑versus‑host disease
Author(s)
Christine Duncan, MD
Senior Physician | Dana-Farber
Boston Children's Cancer and Blood Disorders Center
Medical Director of Clinical Research and Clinical Development, Gene Therapy Program | Boston Children’s Hospital
Associate Professor of Pediatrics | Harvard Medical School
Lisa DelSignore, MD
Associate Professor, Fellowship Program Director, Pediatric Critical Care Medicine | Yale University
Citation
Duncan C, DelSignore L. Graft-Versus-Host Disease. 3/2017. Online Video. OPENPediatrics. https://learn.openpediatrics.org/learn/course/internal/view/elearning/3255/graft-versus-host-disease.
